| Rank | Name | IP | G | BR/9 | Yrs | Career Positions | Career | 200+ inning seasons after age 22 |
| 1 | Bob Feller | 1449.0 | 205 | 12.2 | 6 | P | 1936-1956 | 6 |
| 2 | Pete Schneider | 1253.0 | 200 | 12.4 | 5 | P | 1914-1919 | 0 |
| 3 | Bert Blyleven | 1054.0 | 144 | 10.2 | 4 | P | 1970-1992 | 13 |
| 4 | Walter Johnson | 1038.1 | 135 | 9.0 | 4 | P OF | 1907-1927 | 15 |
| 5 | Joe Wood | 1002.2 | 152 | 9.4 | 5 | OF P 2B 1B | 1908-1922 | 0 |
| 6 | Mike McCormick | 989.0 | 196 | 11.6 | 6 | P | 1956-1971 | 2 |
| 7 | Larry Dierker | 981.0 | 144 | 10.3 | 6 | P | 1964-1977 | 4 |
| 8 | Earl Hamilton | 946.0 | 148 | 11.6 | 4 | P | 1911-1924 | 4 |
| 9 | Chief Bender | 940.2 | 136 | 10.3 | 4 | P 1B 3B OF | 1903-1925 | 5 |
| 10 | Dwight Gooden | 924.1 | 124 | 9.7 | 4 | P | 1984- | 4 |
| 11 | Babe Ruth | 890.1 | 121 | 9.9 | 4 | OF P 1B | 1914-1935 | 0 |
| 12 | Frank Tanana | 840.0 | 111 | 10.0 | 4 | P | 1973-1993 | 11 |
| 13 | Rube Marquard | 821.0 | 131 | 11.3 | 5 | P | 1908-1925 | 9 |
| 14 | Catfish Hunter | 804.0 | 133 | 10.8 | 4 | P 1B | 1965-1979 | 8 |
| 15 | Don Drysdale | 803.0 | 147 | 11.2 | 4 | P | 1956-1969 | 10 |
| 16 | Lee Meadows | 799.0 | 133 | 11.8 | 3 | P | 1915-1929 | 9 |
| 17 | Johnny Lush | 792.2 | 112 | 11.3 | 5 | P OF 1B | 1904-1910 | 2 |
| 18 | Art Houtteman | 787.0 | 155 | 12.2 | 6 | P | 1945-1957 | 1 |
| 19 | Waite Hoyt | 774.0 | 116 | 12.1 | 5 | P | 1918-1938 | 8 |
| 20 | Fernando Valenzuela | 752.0 | 107 | 10.6 | 4 | P 1B OF | 1980-1997 | 5 |
| 21 | Gary Nolan | 737.0 | 109 | 10.6 | 4 | P | 1967-1977 | 3 |
| 22 | Milt Pappas | 737.0 | 124 | 11.2 | 5 | P 2B | 1957-1973 | 7 |
| 23 | Ralph Branca | 718.0 | 140 | 11.9 | 5 | P | 1944-1956 | 1 |
| 24 | Pol Perritt | 712.0 | 118 | 11.8 | 4 | P | 1912-1921 | 3 |
| 25 | Hal Newhouser | 691.0 | 137 | 13.8 | 5 | P | 1939-1955 | 7 |
| 26 | Mel Harder | 690.2 | 149 | 13.6 | 5 | P | 1928-1947 | 7 |
| 27 | Ray Sadecki | 675.0 | 115 | 13.0 | 4 | P | 1960-1977 | 2 |
| 28 | Don Gullett | 659.0 | 155 | 10.9 | 4 | P | 1970-1978 | 1 |
| 29 | George Baumgardner | 655.1 | 113 | 12.2 | 3 | P | 1912-1916 | 0 |
| 30 | Chuck Stobbs | 642.0 | 140 | 13.3 | 6 | P | 1947-1961 | 2 |
| 31 | Wally Bunker | 638.0 | 122 | 11.0 | 5 | P | 1963-1971 | 1 |
| 32 | Pete Donohue | 634.0 | 96 | 11.6 | 3 | P | 1921-1932 | 3 |
| 33 | Dennis Eckersley | 633.0 | 103 | 10.5 | 3 | P | 1975-1998 | 5 |
| 34 | Joe Coleman | 632.0 | 104 | 11.5 | 5 | P | 1965-1979 | 6 |
| 35 | Al Mamaux | 628.0 | 97 | 10.7 | 4 | P | 1913-1924 | 0 |
| 36 | Denny McLain | 605.0 | 93 | 10.4 | 4 | P | 1963-1972 | 4 |
| 37 | Sam McDowell | 605.0 | 113 | 12.3 | 5 | P 1B 2B | 1961-1975 | 5 |
| 38 | Paul Dean | 595.0 | 102 | 11.0 | 3 | P | 1934-1943 | 0 |
| 39 | Harry Harper | 584.2 | 113 | 11.7 | 5 | P | 1913-1923 | 2 |
| 40 | George Mullin | 580.2 | 76 | 11.9 | 2 | P OF | 1902-1915 | 10 |
| 41 | Bill Bailey | 578.0 | 101 | 12.1 | 5 | P OF | 1907-1922 | 1 |
| 42 | Dick Ellsworth | 575.0 | 106 | 13.0 | 4 | P | 1958-1971 | 4 |
| 43 | Carl Scheib | 562.0 | 116 | 13.8 | 6 | P OF | 1943-1954 | 0 |
| 44 | Joe Bush | 560.0 | 103 | 12.4 | 4 | P OF | 1912-1928 | 9 |
| 45 | Wes Ferrell | 557.0 | 89 | 12.8 | 4 | P OF | 1927-1941 | 6 |
| 46 | George Ferguson | 551.0 | 110 | 11.8 | 4 | P | 1906-1911 | 0 |
| 47 | Bret Saberhagen | 549.0 | 100 | 10.1 | 3 | P | 1984- | 3 |
| 48 | Willie Mitchell | 547.2 | 97 | 11.4 | 4 | P OF | 1909-1919 | 3 |
| 49 | Bob Moose | 546.0 | 112 | 10.8 | 4 | P | 1967-1976 | 2 |
| 50 | Doc Crandall | 545.0 | 104 | 10.6 | 3 | P 2B SS OF 1B | 1908-1918 | 1 |
| 51 | Earl Moore | 544.1 | 67 | 12.3 | 2 | P | 1901-1914 | 7 |
| 52 | Vida Blue | 544.0 | 82 | 9.3 | 4 | P | 1969-1986 | 8 |
| 53 | Steve Avery | 543.0 | 91 | 11.8 | 3 | P | 1990- | 1 |
| 54 | George Kaiserling | 536.2 | 78 | 11.8 | 2 | P | 1914-1915 | 0 |
| 55 | Dave Morehead | 535.0 | 95 | 13.0 | 3 | P | 1963-1970 | 0 |
| 56 | Ken Holtzman | 533.0 | 83 | 11.2 | 4 | P | 1965-1979 | 7 |
| 57 | Rick Wise | 531.0 | 113 | 11.8 | 4 | P | 1964-1982 | 8 |
| 58 | Storm Davis | 526.0 | 98 | 11.0 | 3 | P | 1982-1994 | 1 |
| 59 | Curt Simmons | 525.0 | 101 | 12.8 | 4 | P | 1947-1967 | 7 |
| 60 | Dave Rozema | 524.0 | 72 | 10.9 | 3 | P | 1977-1986 | 0 |
| 61 | Dave Boswell | 521.0 | 96 | 10.5 | 4 | P | 1964-1971 | 1 |
| 62 | Nick Maddox | 518.0 | 73 | 9.6 | 3 | P | 1907-1910 | 0 |
| 63 | Willis Hudlin | 517.0 | 93 | 12.8 | 3 | P | 1926-1944 | 4 |
| 64 | Pedro Ramos | 513.0 | 125 | 12.9 | 3 | P | 1955-1970 | 5 |
| 65 | Jimmy Dygert | 510.2 | 83 | 10.6 | 3 | P | 1905-1910 | 2 |
| 66 | Jim Shaw | 509.1 | 101 | 11.7 | 4 | P | 1913-1921 | 4 |
| 67 | Bob Friend | 506.0 | 101 | 13.5 | 3 | P | 1951-1966 | 11 |
| 68 | Jerry Walker | 506.0 | 114 | 12.3 | 5 | P | 1957-1964 | 0 |
| 69 | Van Lingle Mungo | 502.0 | 85 | 12.3 | 3 | P | 1931-1945 | 3 |
| 70 | Billy Hoeft | 498.0 | 97 | 12.8 | 3 | P | 1952-1966 | 3 |
| 71 | George Kahler | 496.0 | 83 | 13.2 | 3 | P | 1910-1914 | 0 |
| 72 | Dave McNally | 493.0 | 95 | 12.4 | 4 | P | 1962-1975 | 8 |
| 73 | Dutch Leonard | 484.1 | 78 | 9.9 | 2 | P | 1913-1925 | 4 |
| 74 | Jack Fisher | 483.0 | 103 | 12.0 | 3 | P | 1959-1969 | 4 |
| 75 | Jim Scott | 479.2 | 77 | 10.4 | 2 | P | 1909-1917 | 4 |
| 76 | Dean Chance | 473.0 | 100 | 11.8 | 3 | P | 1961-1971 | 5 |
| 77 | Bill James | 468.0 | 70 | 11.0 | 2 | P | 1913-1919 | 0 |
| 78 | Bill Stafford | 468.0 | 82 | 10.8 | 3 | P | 1960-1967 | 0 |
| 79 | Alex Fernandez | 467.0 | 76 | 12.7 | 3 | P | 1990- | 4 |
| 80 | Mike Witt | 462.2 | 98 | 12.5 | 3 | P | 1981-1993 | 6 |
| 81 | Byron Houck | 459.1 | 91 | 12.7 | 3 | P | 1912-1918 | 0 |
| 82 | Don Sutton | 459.0 | 74 | 10.3 | 2 | P | 1966-1988 | 18 |
| 83 | Terry Forster | 457.0 | 217 | 12.0 | 4 | P OF | 1971-1986 | 0 |
| 84 | Mark Lemongello | 454.0 | 71 | 11.7 | 3 | P | 1976-1979 | 1 |
| 85 | George Uhle | 449.2 | 94 | 13.0 | 3 | P C | 1919-1936 | 7 |
| 86 | Jack Russell | 446.0 | 102 | 12.2 | 3 | P | 1926-1940 | 3 |
| 87 | Camilo Pascual | 437.0 | 130 | 14.4 | 3 | P | 1954-1971 | 6 |
| 88 | Greg Maddux | 435.2 | 70 | 12.8 | 3 | P | 1986- | 11 |
| 89 | Lindy McDaniel | 435.0 | 99 | 12.6 | 4 | P | 1955-1975 | 0 |
| 90 | Virgil Cheeves | 435.0 | 100 | 13.6 | 4 | P | 1920-1927 | 0 |
| 91 | Lefty Tyler | 432.0 | 72 | 13.8 | 3 | P 1B | 1910-1921 | 6 |
| 92 | Clay Kirby | 431.0 | 71 | 13.0 | 2 | P | 1969-1976 | 3 |
| 93 | Steve Barber | 430.0 | 73 | 12.2 | 2 | P | 1960-1974 | 2 |
| 94 | Johnny Podres | 426.0 | 89 | 12.8 | 3 | P | 1953-1969 | 3 |
| 95 | Erv Palica | 426.0 | 136 | 12.4 | 4 | P | 1945-1956 | 0 |
| 96 | Lary Sorensen | 423.0 | 60 | 10.9 | 2 | P | 1977-1988 | 2 |
| 97 | Tommy Hughes | 423.0 | 74 | 12.6 | 2 | P | 1941-1948 | 0 |
| 98 | Dick Drott | 423.0 | 85 | 13.5 | 3 | P | 1957-1963 | 0 |
| 99 | Marcelino Lopez | 420.0 | 76 | 11.5 | 3 | P | 1963-1972 | 0 |
| 100 | Moe Drabowsky | 417.0 | 67 | 12.4 | 3 | P | 1956-1972 | 0 |